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Structure of 36556-33-9
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1,3,5-Trichloro-2-fluorobenzene features a highly electron-deficient aromatic ring stabilized by orthogonal halogen substituents. This configuration enables selective electrophilic substitution and facilitates coupling reactions under mild conditions. The molecule exhibits excellent bench stability and compatibility with diverse synthetic workflows.
1,3,5-Trichloro-2-fluorobenzene serves as a versatile electrophilic building block in aromatic substitution chemistry. Its orthogonal halogenation pattern enables sequential functionalization via palladium-catalyzed cross-coupling reactions. The fluorine atom enhances metabolic stability and modulates electronic properties, making it valuable for constructing bioactive heterocycles and pharmaceutical intermediates. Bench-stable and readily purified by distillation, it facilitates scalable synthesis of complex molecular architectures.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: