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Structure of 3678-63-5
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4-Chloro-2-picoline is a chlorinated pyridine derivative featuring a chlorine substituent at the para position relative to the nitrogen. This electron-deficient heterocycle integrates readily into cross-coupling reactions and serves as a key building block in pharmaceutical synthesis. The molecule exhibits enhanced reactivity due to the combined influence of the electron-withdrawing chlorine and the basic nitrogen atom.
4-Chloro-2-picoline serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling direct functionalization at the pyridine ring due to its activated C–Cl bond. Its ortho-directing methyl group facilitates selective metallation or electrophilic substitution, while the chlorine atom undergoes reliable cross-coupling reactions with palladium catalysts. The compound exhibits good bench stability and is compatible with standard purification methods, making it a practical choice for constructing nitrogen-containing heterocyclic scaffolds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: