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CS-W001157 4
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1-Methyl-1h-pyrrole-3-carbaldehyde

  • CAS No. 36929-60-9

  • Cat. No. CS-0116718
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-Methyl-1h-pyrrole-3-carbaldehyde|CS-0116718

Structure of 36929-60-9

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General Information

  • CAS No. 36929-60-9
  • Cat. No. CS-0116718
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇NO
  • Molecular Weight 109.13
  • Synonym(s) 1H-Pyrrole-3-carboxaldehyde,1-methyl
  • SMILES O=CC1=CN(C)C=C1

Description

1-Methyl-1H-pyrrole-3-carbaldehyde is a bench-stable, electron-rich heteroaromatic aldehyde featuring a methyl-substituted pyrrole ring with a formyl group at the 3-position. This structure enables direct incorporation into cross-coupling reactions and condensation-based syntheses, offering high reactivity under mild conditions.

Application

1-Methyl-1H-pyrrole-3-carbaldehyde serves as a versatile building block in heterocyclic synthesis, enabling efficient access to pyrrole-based scaffolds through standard functional group transformations. Its aldehyde functionality facilitates reductive amination, Wittig reactions, and coupling with nucleophiles under mild conditions. The methyl substituent enhances stability and modulates electronic properties, improving handling and purification. This compound functions reliably in multistep syntheses for pharmaceutical intermediates and agrochemicals.

Synthesis

  • Route1
    • In-stock
      2,5-Dimethoxy-2,5-dihydrofuran|CS-W016547
      332-77-4
    • null|null
      201230-82-2
    • null|null
      74-89-5
    • ~48%
    • In-stock
      1-Methyl-1h-pyrrole-3-carbaldehyde|CS-0116718
      36929-60-9

    References

    • Brezhnev, L. Yu.; Vartanyan, M. M.; Vol'f, E. Yu.; Solov'eva, T. Yu.; Rodin, A. P. Chemistry of Heterocyclic Compounds (New York, NY, United States), 1990 , vol. 26, # 9 p. 1073 Khimiya Geterotsiklicheskikh Soedinenii, 1990 , vol. 26, # 9 p. 1285
  • Route2
    • null|null
      50634-05-4
    • null|null
      74-89-5
    • ~%
    • In-stock
      1-Methyl-1h-pyrrole-3-carbaldehyde|CS-0116718
      36929-60-9

    References

    • American Cyanamid Company Patent: US5108485 A1, 1992 ;
  • Route3
    • In-stock
      Pyrrole-3-carboxaldehyde|CS-D1061
      7126-39-8
    • null|null
      74-88-4
    • ~82%
    • In-stock
      1-Methyl-1h-pyrrole-3-carbaldehyde|CS-0116718
      36929-60-9

    References

    • Purkarthofer, Thomas; Gruber, Karl; Fechter, Martin H.; Griengl, Herfried Tetrahedron, 2005 , vol. 61, # 32 p. 7661 - 7668

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H227-H315-H319-H335
Precautionary Statements : P210-P261-P264-P271-P280-P302+P352-P304+P340-P362-P370+P378-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   22
  • LogP   0.8376
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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