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Structure of 36947-69-0
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2-(tert-Butyl)-1H-imidazole features a sterically hindered tert-butyl group that enhances stability and modulates reactivity. This bench-stable imidazole derivative serves as a robust nitrogen donor in catalytic systems, particularly in transition metal-catalyzed C–H functionalization and cross-coupling reactions. The bulky substituent reduces undesired coordination while maintaining nucleophilicity.
2-(tert-Butyl)-1H-imidazole serves as a robust, bench-stable imidazole scaffold with enhanced solubility and steric protection. It functions as a versatile building block in medicinal chemistry, enabling efficient access to substituted imidazoles via electrophilic substitution or metal-catalyzed coupling. The tert-butyl group provides favorable steric and electronic modulation, improving functional group tolerance and simplifying purification in multi-step syntheses.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: