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Structure of 37131-91-2
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6-Chloropyrimidine-4-carboxylic acid features a chlorine atom at the 6-position and a carboxylic acid group at the 4-position on a pyrimidine core, enabling direct incorporation into heterocyclic scaffolds. The electron-deficient pyrimidine ring enhances reactivity in nucleophilic substitution and coupling processes. This derivative serves as a key building block for pharmaceutical intermediates and agrochemicals, offering improved solubility and stability under standard conditions.
6-Chloropyrimidine-4-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C4 position via nucleophilic substitution or coupling reactions. Its bench-stable nature and tolerance to diverse reaction conditions facilitate efficient synthesis of pyrimidine-based scaffolds. The carboxylic acid group supports derivatization into amides, esters, or activated acyl intermediates, while the 6-chloro substituent provides a reliable handle for cross-coupling or bioisosteric replacement in drug discovery workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: