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CS-W001157 4
Total: USD 88.00

6-Chloropyrimidine-4-carboxylic acid

  • CAS No. 37131-91-2

  • Cat. No. CS-W005983
  • Purity≥95%
  • MDL No.MFCD08692928
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

6-Chloropyrimidine-4-carboxylic acid|CS-W005983

Structure of 37131-91-2

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Description

6-Chloropyrimidine-4-carboxylic acid features a chlorine atom at the 6-position and a carboxylic acid group at the 4-position on a pyrimidine core, enabling direct incorporation into heterocyclic scaffolds. The electron-deficient pyrimidine ring enhances reactivity in nucleophilic substitution and coupling processes. This derivative serves as a key building block for pharmaceutical intermediates and agrochemicals, offering improved solubility and stability under standard conditions.

Application

6-Chloropyrimidine-4-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C4 position via nucleophilic substitution or coupling reactions. Its bench-stable nature and tolerance to diverse reaction conditions facilitate efficient synthesis of pyrimidine-based scaffolds. The carboxylic acid group supports derivatization into amides, esters, or activated acyl intermediates, while the 6-chloro substituent provides a reliable handle for cross-coupling or bioisosteric replacement in drug discovery workflows.

General Information

  • CAS No. 37131-91-2
  • Cat. No. CS-W005983
  • Purity ≥95%
  • MDL No. MFCD08692928
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃ClN₂O₂
  • Molecular Weight 158.54
  • Synonym(s) None
  • SMILES OC(=O)C1=NC=NC(Cl)=C1

Computational Chemistry Data

  • TPSA   63.08
  • LogP   0.8282
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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