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CS-W001157 4
Total: USD 88.00

Trimethyl(p-tolyl)silane

  • CAS No. 3728-43-6

  • Cat. No. CS-0153085
  • Molecule weight164.32
  • Purity≥97%
  • MDL No.MFCD00014850

*For research and further manufacturing use only, not for direct human use.

Trimethyl(p-tolyl)silane|CS-0153085

Structure of 3728-43-6

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General Information

  • CAS No. 3728-43-6
  • Cat. No. CS-0153085
  • Purity ≥97%
  • MDL No. MFCD00014850
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₆Si
  • Molecular Weight 164.32
  • Synonym(s) Trimethylptolylsilane
  • SMILES CC1=CC=C(C=C1)[Si](C)(C)C

Description

Trimethyl(p-tolyl)silane features a sterically protected silicon center with a para-methyl aryl group, enhancing stability and facilitating selective functionalization. This bench-stable reagent integrates readily into cross-coupling protocols, delivering robust silane transfer under mild conditions.

Application

Trimethyl(p-tolyl)silane serves as a stable, bench-ready silylating agent that facilitates efficient protection of alcohols and carboxylic acids under mild conditions. Its ortho-substituted aryl group enhances steric shielding and thermal stability, enabling selective transformations in complex molecule synthesis. The reagent exhibits excellent functional group tolerance and is compatible with standard purification protocols, making it a reliable choice for iterative synthetic sequences in medicinal chemistry and process development.

Safety Information

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GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H225-H315-H319-H335
Precautionary Statements : P210-P233-P240-P241-P242-P243-P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P370+P378-P405-P501

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Computational Chemistry Data

  • TPSA   0
  • LogP   2.54022
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   1

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