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CS-W001157 4
Total: USD 88.00

(5-Methylpyridin-2-yl)boronic acid

  • CAS No. 372963-49-0

  • Cat. No. CS-W018321
  • Purity≥96%
  • MDL No.None
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

(5-Methylpyridin-2-yl)boronic acid|CS-W018321

Structure of 372963-49-0

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Description

This boronate moiety integrates readily into Suzuki-Miyaura cross-coupling reactions under standard conditions, offering enhanced stability and solubility in polar aprotic solvents. The methyl group at the 5-position provides steric and electronic tuning, improving reaction efficiency while maintaining bench-stable handling.

Application

(5-Methylpyridin-2-yl)boronic acid serves as a versatile building block in cross-coupling reactions, enabling efficient C–C bond formation under palladium catalysis. Its pyridine core offers enhanced solubility and stability compared to simpler aryl boronic acids, while the methyl group provides mild electronic activation. The compound exhibits excellent functional group tolerance and is readily purified by recrystallization, making it ideal for constructing biologically relevant heterocyclic scaffolds in medicinal chemistry and materials science applications.

General Information

  • CAS No. 372963-49-0
  • Cat. No. CS-W018321
  • Purity ≥96%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₈BNO₂
  • Molecular Weight 136.95
  • Synonym(s) 5-Methylpyridine-2-boronic acid
  • SMILES CC1=CN=C(B(O)O)C=C1

Computational Chemistry Data

  • TPSA   53.35
  • LogP   -0.93018
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅲ
Hazard Statements : H315-H318-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

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