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CS-W001157 4
Total: USD 88.00

2-Hydroxy-2-(trifluoromethyl)propionic acid

  • CAS No. 374-35-6

  • Cat. No. CS-0121382
  • Molecule weight158.08
  • Purity≥97%
  • MDL No.MFCD00190646

*For research and further manufacturing use only, not for direct human use.

2-Hydroxy-2-(trifluoromethyl)propionic acid|CS-0121382

Structure of 374-35-6

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General Information

  • CAS No. 374-35-6
  • Cat. No. CS-0121382
  • Purity ≥97%
  • MDL No. MFCD00190646
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₅F₃O₃
  • Molecular Weight 158.08
  • Synonym(s) Propanoic acid, 3,3,3-trifluoro-2-hydroxy-2-methyl-
  • SMILES CC(C(F)(F)F)(O)C(O)=O

Application

2-Hydroxy-2-(trifluoromethyl)propionic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of trifluoromethylated β-hydroxy acids and related heterocyclic scaffolds. Its stability under standard reaction conditions and compatibility with diverse functional groups facilitate efficient derivatization. The molecule functions as a key precursor in the construction of bioactive compounds where enhanced metabolic stability and lipophilicity are required.

Synthesis

  • Route1
    • In-stock
      2-Hydroxy-2-(trifluoromethyl)propionic acid|CS-0121382
      374-35-6
    • ~%
    • In-stock
      2-Hydroxy-2-(trifluoromethyl)propionic acid|CS-0121382
      374-35-6

    References

    • Darrall et al. Journal of the Chemical Society, 1951 , p. 2329,2330
  • Route2
    • 3,3,3-Trifluoro-2-hydroxy-2-methylpropanamide|CS-0878209
      114645-34-0
    • ~45%
    • In-stock
      2-Hydroxy-2-(trifluoromethyl)propionic acid|CS-0121382
      374-35-6

    References

    • Fuhshuku, Ken-Ichi; Watanabe, Shunsuke; Nishii, Tetsuro; Ishii, Akihiro; Asano, Yasuhisa Journal of Molecular Catalysis B: Enzymatic, 2014 , vol. 102, p. 115 - 119
  • Route3
    • null|null
      693287-30-8
    • ~35%
    • In-stock
      2-Hydroxy-2-(trifluoromethyl)propionic acid|CS-0121382
      374-35-6

    References

    • Tosoh Corporation Patent: EP1422226 A1, 2004 ; Location in patent: Page 12 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314-H318
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   57.53
  • LogP   0.3843
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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