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3-Bromo-2-hydroxy-6-picoline

  • CAS No. 374633-33-7

  • Cat. No. CS-0034716
  • Purity≥97%
  • MDL No.MFCD03095217

*For research and further manufacturing use only, not for direct human use.

3-Bromo-2-hydroxy-6-picoline|CS-0034716

Structure of 374633-33-7

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General Information

  • CAS No. 374633-33-7
  • Cat. No. CS-0034716
  • Purity ≥97%
  • MDL No. MFCD03095217
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆BrNO
  • Molecular Weight 188.02
  • Synonym(s) 5-Bromo-6-hydroxy-2-picoline
  • SMILES O=C1C(Br)=CC=C(C)N1

Description

3-Bromo-2-hydroxy-6-picoline features a bromine substituent at the 3-position and a hydroxyl group at the 2-position on a picoline scaffold, delivering a uniquely reactive site for nucleophilic substitution and functionalization. This bench-stable, moisture-tolerant compound integrates readily into synthetic sequences requiring selective C–Br activation or orthogonal protection strategies.

Application

3-Bromo-2-hydroxy-6-picoline serves as a versatile building block for heterocyclic synthesis, enabling efficient access to substituted pyridine scaffolds. The bromo group facilitates palladium-catalyzed cross-coupling reactions, while the adjacent hydroxyl group offers orthogonal functionalization potential. Its bench-stable nature and compatibility with standard purification methods make it well-suited for medicinal chemistry campaigns and process development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   32.86
  • LogP   1.44582
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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