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Structure of 37470-46-5
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4-Hydroxy-3-iodobenzoic acid features a strategically positioned iodine atom and hydroxyl group on the aromatic ring, enabling direct functionalization in cross-coupling reactions. The carboxylic acid moiety provides a handle for amide bond formation or salt generation. This compound serves as a key intermediate in the synthesis of bioactive molecules and radiolabeled probes, offering excellent stability under standard bench conditions.
4-Hydroxy-3-iodobenzoic acid serves as a versatile building block for palladium-catalyzed cross-coupling reactions, enabling efficient access to substituted phenolic scaffolds. The ortho-iodo and hydroxyl groups provide orthogonal reactivity for sequential functionalization, while the carboxylic acid facilitates derivatization or conjugation. Its bench-stable crystalline form simplifies handling and purification in synthetic workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: