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CS-W001157 4
Total: USD 88.00

(S)-1-Chloropropan-2-ol

  • CAS No. 37493-16-6

  • Cat. No. CS-0158252
  • Purity≥98%
  • MDL No.MFCD01862133

*For research and further manufacturing use only, not for direct human use.

(S)-1-Chloropropan-2-ol|CS-0158252

Structure of 37493-16-6

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General Information

  • CAS No. 37493-16-6
  • Cat. No. CS-0158252
  • Purity ≥98%
  • MDL No. MFCD01862133
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₇ClO
  • Molecular Weight 94.54
  • Synonym(s) (S)-1-Chloro-2-propanol
  • SMILES C[C@@H](CCl)O

Description

(S)-1-Chloropropan-2-ol is a chiral synthetically valuable intermediate featuring a stereodefined secondary alcohol and adjacent chlorine atom. This configuration enables selective transformations in asymmetric synthesis, particularly in the construction of enantiopure pharmaceuticals and agrochemicals. The molecule exhibits favorable reactivity under standard conditions, integrating readily into nucleophilic substitution and elimination cascades.

Application

(S)-1-Chloropropan-2-ol serves as a chiral building block for the synthesis of pharmaceutical intermediates and asymmetric catalysts. Its well-defined stereochemistry enables stereoselective transformations, while its hydroxyl and chloride functionalities offer orthogonal reactivity for downstream functionalization. The compound exhibits good bench stability and facilitates efficient purification, making it suitable for scale-up in medicinal chemistry workflows.

Synthesis

  • Route1
    • null|null
      16088-62-3
    • ~%
    • In-stock
      (S)-2-Chloropropan-1-ol|CS-W016664
      19210-21-0
    • In-stock
      (S)-1-Chloropropan-2-ol|CS-0158252
      37493-16-6

    References

    • US2011/130377 A1, ; Page/Page column 19 ;
  • Route2
    • null|null
      187737-37-7
    • ~%
    • null|null
      78-89-7
    • In-stock
      (S)-1-Chloropropan-2-ol|CS-0158252
      37493-16-6
    • In-stock
      (R)-1-Chloropropan-2-ol|CS-W005784
      19141-39-0

    References

    • Journal of Organic Chemistry, , vol. 63, # 9 p. 2790 - 2791
  • Route3
    • null|null
      127-00-4
    • ~72%
    • In-stock
      (S)-1-Chloropropan-2-ol|CS-0158252
      37493-16-6

    References

    • Cambou, Bernard; Klibanov, Alexander M. Journal of the American Chemical Society, 1984 , vol. 106, # 9 p. 2687 - 2692

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H226-H332-H315-H319-H335
Precautionary Statements : P210-P233-P240-P241-P242-P243-P260-P261-P264-P271-P280-P302+P352-P303+P361+P353-P304+P340-P304+P341-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P370+P378-P403+P233-P403+P235-P405-P501

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   0.606
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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