2-Chloro-5-fluoro-4-methoxypyrimidine

Name: 2-Chloro-5-fluoro-4-methoxypyrimidine
Brand: ChemScene
Availability: InStock
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CAS No. 37554-70-4
Cat. No. CS-0045717
Purity≥97%
MDL No.MFCD07440062

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Chloro-5-fluoro-4-methoxypyrimidine|CS-0045717

Structure of 37554-70-4

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Description

2-Chloro-5-fluoro-4-methoxypyrimidine features a trifunctional pyrimidine core with orthogonal reactivity, enabling selective coupling in heterocyclic synthesis. The electron-deficient ring facilitates nucleophilic substitution at the chloro position, while the methoxy and fluoro groups provide steric and electronic control for downstream functionalization. This bench-stable compound serves as a key intermediate in agrochemical and pharmaceutical development workflows.

Application

2-Chloro-5-fluoro-4-methoxypyrimidine serves as a versatile building block in heterocyclic synthesis, enabling efficient construction of pyrimidine-based scaffolds. Its orthogonal reactivity—where the chlorine and fluorine substituents undergo selective nucleophilic substitution—facilitates the modular introduction of diverse aryl, heteroaryl, and amine functionalities. The methoxy group enhances solubility and stability during handling, while the compound exhibits robust bench stability and compatibility with standard coupling protocols. Widely employed in medicinal chemistry and agrochemical research, it functions as a key intermediate in the synthesis of kinase inhibitors and antiviral agents.

General Information

CAS No. 37554-70-4
Cat. No. CS-0045717
Purity ≥97%
MDL No. MFCD07440062
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₄ClFN₂O
Molecular Weight 162.55
Synonym(s) 2-Chloro-5-fluoro-4-methoxy-1,3-diazine
SMILES COC1=NC(Cl)=NC=C1F

Computational Chemistry Data

TPSA 35.01
LogP 1.2777
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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2-Chloro-5-fluoro-4-methoxypyrimidine

CAS No. 37554-70-4

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