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Structure of 376348-75-3
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4,4-Difluorocyclohexane-1-carbonyl chloride features a fluorinated cyclohexane core with a reactive acyl chloride group, enabling direct incorporation into complex molecular architectures. The geminal difluoro substitution enhances metabolic stability and modulates electronic properties, making this reagent valuable for medicinal chemistry applications requiring robust, lipophilic linkages.
4,4-Difluorocyclohexane-1-carbonyl chloride serves as a versatile acylating agent for the synthesis of fluorinated carbonyl compounds. Its reactivity facilitates efficient amide and ester formation under mild conditions, with the gem-difluoro substitution enhancing metabolic stability in bioactive molecule construction. The compound exhibits good bench stability and is compatible with common functional groups, enabling straightforward purification and integration into multi-step synthetic sequences.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 3265
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H227-H314
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Precautionary Statements : P210-P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P370+P378-P403+P235-P405-P501
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Lot numbers can be found on the outside label of a product: