N-Boc-D-proline

Name: N-Boc-D-proline
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 37784-17-1
Cat. No. CS-D0669
Purity≥98%
MDL No.MFCD00063226

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Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Structure of 37784-17-1

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Description

N-Boc-D-proline features a stable tert-butoxycarbonyl-protected amine and a chiral pyrrolidine ring, enabling reliable incorporation into peptide synthesis and asymmetric catalysis. This bench-stable derivative facilitates efficient coupling reactions under standard conditions while maintaining stereochemical integrity during iterative transformations.

Application

N-Boc-D-proline serves as a versatile chiral building block in asymmetric synthesis, enabling efficient construction of pyrrolidine-containing scaffolds. The Boc group provides excellent stability and ease of removal under mild acidic conditions, while the D-proline moiety offers predictable stereocontrol in enantioselective catalysis and peptide coupling. Its functional group tolerance and compatibility with standard coupling reagents make it ideal for iterative synthetic sequences in medicinal chemistry and process development.

General Information

CAS No. 37784-17-1
Cat. No. CS-D0669
Purity ≥98%
MDL No. MFCD00063226
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₇NO₄
Molecular Weight 215.25
Synonym(s) None
SMILES O=C(OC(C)(C)C)N(CCC1)[C@H]1C(O)=O

Computational Chemistry Data

TPSA 66.84
LogP 1.4705
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Bioactive Molecules Dye and Bio-assay Reagents

Building Blocks Functional Group Boc

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Amino Acids and their Derivatives Proline and derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Peptide Chemistry Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Peptide Chemistry Amino Acid Derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

Biochemistry Biochemicals and Reagents Amino Acids N-Protected Amino Acids

Key Words

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N-Boc-D-proline

CAS No. 37784-17-1

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