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CS-W001157 4
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1,2-Dibromo-4,5-dimethoxybenzene

  • CAS No. 37895-73-1

  • Cat. No. CS-0150615
  • Purity≥95%
  • MDL No.MFCD00014894

*For research and further manufacturing use only, not for direct human use.

1,2-Dibromo-4,5-dimethoxybenzene|CS-0150615

Structure of 37895-73-1

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General Information

  • CAS No. 37895-73-1
  • Cat. No. CS-0150615
  • Purity ≥95%
  • MDL No. MFCD00014894
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈Br₂O₂
  • Molecular Weight 295.96
  • Synonym(s) 4,5-Dibromoveratrole
  • SMILES COC1=C(C=C(C(=C1)Br)Br)OC

Description

1,2-Dibromo-4,5-dimethoxybenzene features two bromine atoms at ortho positions flanking a symmetric dimethoxy substitution pattern. This electron-rich aryl dibromide enables efficient cross-coupling reactions under mild conditions. The methoxy groups enhance solubility and stability, while the defined regiochemistry ensures high selectivity in transition-metal-catalyzed transformations. A reliable building block for complex aromatic scaffolds.

Application

1,2-Dibromo-4,5-dimethoxybenzene serves as a versatile dihalogenated building block for palladium-catalyzed cross-coupling reactions. The dimethoxy substituents enhance solubility and stabilize the aromatic core, while the ortho-bromine atoms enable sequential functionalization. Its bench-stable nature and compatibility with standard coupling protocols facilitate efficient construction of complex biaryl architectures in medicinal chemistry and materials synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   18.46
  • LogP   3.2288
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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