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CS-W001157 4
Total: USD 88.00

4,4'-Thiodipyridine

  • CAS No. 37968-97-1

  • Cat. No. CS-0205274
  • Molecule weight188.25
  • Purity≥98%
  • MDL No.MFCD00059784

*For research and further manufacturing use only, not for direct human use.

4,4'-Thiodipyridine|CS-0205274

Structure of 37968-97-1

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General Information

  • CAS No. 37968-97-1
  • Cat. No. CS-0205274
  • Purity ≥98%
  • MDL No. MFCD00059784
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₈N₂S
  • Molecular Weight 188.25
  • Synonym(s) 4,4'-Dipyridyl sulfide
  • SMILES N=1C=CC(SC=2C=CN=CC2)=CC1

Description

4,4'-Thiodipyridine features a rigid, electron-deficient backbone with two pyridine rings linked by a disulfide bridge, enabling strong coordination to transition metals. This structural motif facilitates use in constructing metal-organic frameworks and redox-active ligands. The compound exhibits bench-stable handling and compatibility with diverse synthetic environments.

Application

4,4'-Thiodipyridine serves as a versatile bifunctional building block in synthetic chemistry, enabling the construction of heterocyclic scaffolds and metal-ligand architectures. Its dual pyridine rings linked by a thioether bridge provide robust stability and orthogonal reactivity, facilitating selective functionalization and coordination in catalytic systems. The compound exhibits excellent bench stability and ease of purification, making it well-suited for iterative synthesis and scale-up applications in medicinal chemistry and materials science.

Synthesis

  • Route1

    References

    • Shionogi and Co., Ltd. Patent: US4960879 A1, 1990 ;
  • Route2

    References

    • Shionogi and Co., Ltd. Patent: US4960879 A1, 1990 ;
  • Route3

    References

    • Li, Yaming; Nie, Caiping; Wang, Huifeng; Li, Xiaoying; Verpoort, Francis; Duan, Chunying European Journal of Organic Chemistry, 2011 , # 36 p. 7331 - 7338

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

Quality Control

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   2.6278
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

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