Lot numbers can be found on the outside label of a product:
Methyl 5-bromo-6-hydroxynicotinate
-
CAS No. 381247-99-0
- Cat. No. CS-0061828
- Purity≥97%
- MDL No.None
*For research and further manufacturing use only, not for direct human use.
Structure of 381247-99-0
Please choose your location and provide accurate information for you
| Size |
|
Price | Quantity | |||
|---|---|---|---|---|---|---|
|
* Please select Quantity before adding items. |
||||||
Recommended Products
General Information
- CAS No. 381247-99-0
- Cat. No. CS-0061828
- Purity ≥97%
- MDL No. None
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₇H₆BrNO₃
- Molecular Weight 232.03
- Synonym(s) methyl 5-bromo-6-oxo-1H-pyridine-3-carboxylate
- SMILES COC(=O)C1=CC(=C(N=C1)O)Br
Description
Methyl 5-bromo-6-hydroxynicotinate features a brominated pyridine core with complementary hydroxyl and ester functionalities. This bifunctional scaffold enables direct coupling in cross-coupling reactions and serves as a key intermediate in the synthesis of bioactive heterocycles. The molecule exhibits favorable solubility in common organic solvents and stability under standard bench conditions, facilitating its use in medicinal chemistry and process development workflows.
Application
Methyl 5-bromo-6-hydroxynicotinate serves as a versatile building block in heterocyclic synthesis, enabling selective functionalization at the C5 and C6 positions. The bromo group facilitates palladium-catalyzed cross-coupling reactions, while the hydroxyl function supports derivatization or protection strategies. Its bench-stable nature and compatibility with standard purification methods make it well-suited for iterative synthesis workflows in medicinal chemistry and API development.
Synthesis
-
Route1
-
In-stock
66171-50-4 - ~99%
-
In-stock
381247-99-0
References
-
ASTRAZENECA AB; ASTRAZENECA UK LIMITED Patent: WO2009/106885 A1, 2009 ; Location in patent: Page/Page column 296-297 ; WO 2009/106885 A1
-
-
Route2
-
67-56-1 -
In-stock
41668-13-7 - ~%
-
In-stock
381247-99-0
References
-
CHONG KUN DANG PHARMACEUTICAL CORP.; Lee, SeoHee; Oh, Jung Taek; Lee, JaeKwang; Lee, JaeWon; Bae, Suyeal; Ha, Nina; Lee, Sera Patent: US2014/31335 A1, 2014 ; Location in patent: Paragraph 0042; 0562; 0563 ;
-
-
Route3
-
5006-66-6 - ~%
-
In-stock
381247-99-0
References
-
CHONG KUN DANG PHARMACEUTICAL CORP.; Lee, SeoHee; Oh, Jung Taek; Lee, JaeKwang; Lee, JaeWon; Bae, Suyeal; Ha, Nina; Lee, Sera Patent: US2014/31335 A1, 2014 ;
-
Safety Information
Download SDS|
GHS Pictogram :
|
GHS No : GHS07
|
|
Signal Word : Warning
|
UN#: N/A
|
|
Class : N/A
|
Packing Group : N/A
|
|
Hazard Statements : H315-H319-H335
|
|
|
Precautionary Statements : P261-P280-P302+P352
|
|
Quality Control
Computational Chemistry Data
- TPSA 59.42
- LogP 1.3363
- H_Acceptors 4
- H_Donors 1
- Rotatable_Bonds 1
Similar Products
Other Classifications
Recently Viewed Products
Leave US a Message
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Upload Pictures
|
|
Key Words
- Methyl 5-bromo-6-hydroxynicotinate sigmaMethyl 5-bromo-6-hydroxynicotinate manufacturerMethyl 5-bromo-6-hydroxynicotinate priceMethyl 5-bromo-6-hydroxynicotinate structureMethyl 5-bromo-6-hydroxynicotinate SDSbuy Methyl 5-bromo-6-hydroxynicotinateMethyl 5-bromo-6-hydroxynicotinate supplierMethyl 5-bromo-6-hydroxynicotinate usesMethyl 5-bromo-6-hydroxynicotinate molecular weightprice of Methyl 5-bromo-6-hydroxynicotinateMethyl 5-bromo-6-hydroxynicotinate chemical name formula of Methyl 5-bromo-6-hydroxynicotinate