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Structure of 38154-43-7
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4,7-Dichloro-2-methylquinazoline delivers a sterically accessible quinazoline core featuring electron-withdrawing chlorines at the 4 and 7 positions, enhancing electrophilicity for targeted couplings. The 2-methyl group provides steric protection and improves solubility, enabling reliable incorporation into pharmaceutical intermediates under standard conditions.
4,7-Dichloro-2-methylquinazoline serves as a versatile building block in medicinal chemistry, enabling efficient construction of kinase inhibitor scaffolds. Its dichloro substitution pattern facilitates late-stage functionalization via palladium-catalyzed cross-coupling, while the methyl group provides a handle for further derivatization. The compound exhibits excellent bench stability and compatibility with standard reaction conditions, making it well-suited for modular synthesis workflows in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P280-P302+P352
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Lot numbers can be found on the outside label of a product: