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Structure of 38186-51-5
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Diethyl 4-bromobenzylphosphonate features a brominated benzyl group linked to a phosphonate ester, enabling direct functionalization in cross-coupling reactions. This bench-stable reagent integrates readily into synthetic sequences requiring aryl halide equivalents, offering high compatibility with palladium-catalyzed transformations and efficient access to phosphonate-containing architectures.
Diethyl 4-bromobenzylphosphonate serves as a versatile building block for C–C bond formation via Negishi and Suzuki-Miyaura coupling reactions. The bromide moiety enables palladium-catalyzed cross-coupling with arylboranes and organozinc reagents, while the phosphonate group supports Stetter and Michael addition reactions. Its bench-stable nature and compatibility with diverse functional groups facilitate efficient synthesis of biaryl and heterocyclic scaffolds in medicinal chemistry workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: