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Structure of 383-31-3
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4-Fluoro-N,N-dimethylbenzenesulfonamide features a para-fluorinated aromatic ring paired with a sterically hindered sulfonamide group, delivering enhanced metabolic stability and favorable solubility profiles. This scaffold integrates readily into medicinal chemistry campaigns targeting kinase inhibition and CNS-penetrant drug candidates.
4-Fluoro-N,N-dimethylbenzenesulfonamide serves as a versatile sulfonamide building block in medicinal chemistry, enabling efficient introduction of a fluorinated aromatic scaffold with enhanced metabolic stability. The dimethylamino group provides favorable solubility and synthetic handle for further functionalization, while the sulfonamide moiety offers strong hydrogen-bonding capacity and is compatible with standard coupling reactions. Bench-stable and readily purified by chromatography or recrystallization, it functions effectively in late-stage derivatization and API intermediate synthesis.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: