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CS-W001157 4
Total: USD 88.00

TFA-Gly-OH

  • CAS No. 383-70-0

  • Cat. No. CS-W017664
  • Purity≥97%
  • MDL No.MFCD00029784

*For research and further manufacturing use only, not for direct human use.

TFA-Gly-OH|CS-W017664

Structure of 383-70-0

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General Information

  • CAS No. 383-70-0
  • Cat. No. CS-W017664
  • Purity ≥97%
  • MDL No. MFCD00029784
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₄F₃NO₃
  • Molecular Weight 171.07
  • Synonym(s) None
  • SMILES O=C(O)CNC(C(F)(F)F)=O

Description

TFA-Gly-OH is a trifluoroacetylated glycine derivative featuring a terminal hydroxyl group. This stable, moisture-tolerant reagent facilitates efficient peptide coupling under standard conditions, enabling direct incorporation of N-terminal trifluoroacetyl protection in synthetic sequences.

Application

TFA-Gly-OH serves as a versatile building block in peptide synthesis, enabling efficient N-terminal capping and side-chain protection. Its trifluoroacetyl (TFA) group enhances solubility and stability during reaction sequences, while the C-terminal carboxylic acid facilitates straightforward coupling with amino acids or amines. The compound exhibits excellent functional group tolerance and simplifies purification through its distinct polarity profile, making it well-suited for both solid-phase and solution-phase synthetic workflows.

Synthesis

  • Route1
    • null|null
      431-47-0
    • Glycine, 99%|CS-1269057
      56-40-6
    • ~94%
    • In-stock
      TFA-Gly-OH|CS-W017664
      383-70-0

    References

    • Russian Journal of General Chemistry, , vol. 64, # 5.2 p. 791 - 792 Zhurnal Obshchei Khimii, , vol. 64, # 5 p. 878
  • Route2
    • Glycine, 99%|CS-1269057
      56-40-6
    • null|null
      407-25-0
    • ~95%
    • In-stock
      TFA-Gly-OH|CS-W017664
      383-70-0

    References

    • Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1355 - 1362
  • Route3
    • Glycine, 99%|CS-1269057
      56-40-6
    • ~%
    • In-stock
      TFA-Gly-OH|CS-W017664
      383-70-0

    References

    • US6191150 B1, ; US 6191150 B1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   66.4
  • LogP   -0.2505
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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