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Structure of 383133-28-6
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6-Iodo-1H-indole-2-carboxylic acid features a halogenated indole scaffold with a carboxylic acid group at the 2-position, enabling direct conjugation in cross-coupling and bioconjugation workflows. The iodine moiety facilitates palladium-catalyzed transformations, while the acidic functionality supports salt formation and derivatization. This compound serves as a key intermediate in medicinal chemistry and materials synthesis.
6-Iodo-1H-indole-2-carboxylic acid serves as a versatile building block for the synthesis of biologically active indole derivatives, enabling palladium-catalyzed cross-coupling reactions at the C6 position. The iodide functionality provides high reactivity in Suzuki, Stille, and Negishi couplings, while the carboxylic acid group offers direct handle for amide formation or derivatization. Bench-stable and readily purified by recrystallization, it functions effectively in multi-step synthetic sequences targeting heterocyclic pharmacophores.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: