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Structure of 38533-61-8
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2-Chloro-3-nitro-6-methoxypyridine features a pyridine core functionalized with chlorine, nitro, and methoxy groups at the 2-, 3-, and 6-positions, respectively. This electron-deficient heterocycle serves as a key intermediate in medicinal chemistry, enabling direct coupling reactions under standard conditions. The ortho-chloro and nitro substituents facilitate palladium-catalyzed cross-coupling, while the methoxy group enhances solubility and modulates electronic properties.
2-Chloro-3-nitro-6-methoxypyridine serves as a versatile building block in heterocyclic synthesis, enabling efficient construction of pyridine-based scaffolds via palladium-catalyzed cross-coupling reactions. The chloro group facilitates reliable C–C bond formation under standard Suzuki or Negishi conditions, while the nitro and methoxy substituents provide orthogonal reactivity for sequential functionalization. Bench-stable and amenable to purification by flash chromatography, it supports scalable, high-yield transformations in medicinal chemistry and process development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501
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Lot numbers can be found on the outside label of a product: