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CS-W001157 4
Total: USD 88.00

3,5-Dibromo-2-methylpyridine

  • CAS No. 38749-87-0

  • Cat. No. CS-W021807
  • Molecule weight250.92
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3,5-Dibromo-2-methylpyridine|CS-W021807

Structure of 38749-87-0

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General Information

  • CAS No. 38749-87-0
  • Cat. No. CS-W021807
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅Br₂N
  • Molecular Weight 250.92
  • Synonym(s) 2-Methyl-3,5-dibromopyridine
  • SMILES CC1=NC=C(Br)C=C1Br

Description

3,5-Dibromo-2-methylpyridine features a sterically accessible pyridine core bearing two bromine substituents at the 3 and 5 positions and a methyl group at the 2 position. This electron-deficient heterocycle serves as a robust scaffold for cross-coupling reactions, enabling efficient incorporation into complex molecular architectures under palladium-catalyzed conditions.

Application

3,5-Dibromo-2-methylpyridine serves as a versatile building block in medicinal chemistry and materials science, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The methyl group provides a handle for further functionalization, while the dibromopyridine core offers enhanced stability and predictable regioselectivity in C–C bond formation. Its bench-stable solid form facilitates handling and purification in multi-step syntheses.

Synthesis

  • Route1

    References

    • Gavai, Ashvinikumar V.; Norris, Derek J.; Han, Wen-Ching; Vite, Gregory D.; Fink, Brian E.; Tokarski, John S. Patent: US2005/192310 A1, 2005 ; Location in patent: Page/Page column 35 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.91502
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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