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Structure of 3883-95-2
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3-Bromo-2-hydroxybenzoic acid features a bromine atom at the meta position relative to the carboxylic acid, paired with a phenolic hydroxyl group ortho to the acid. This arrangement enables direct coupling in electrophilic functionalization and facilitates chelation in metal complexation. The molecule exhibits enhanced reactivity for derivatization under mild conditions, particularly useful in synthesizing bioactive heterocycles and pharmaceutical intermediates.
3-Bromo-2-hydroxybenzoic acid serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its ortho-hydroxyl and carboxylic acid functionalities enable efficient metal-catalyzed coupling reactions and cyclization cascades. The bromine atom facilitates palladium-catalyzed cross-couplings, while the phenolic hydroxyl supports directed metallation and derivatization. This compound exhibits good bench stability and is readily purified by recrystallization, making it well-suited for scalable medicinal chemistry campaigns.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: