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CS-W001157 4
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3-Hydrazinyl-6-methylpyridazine

  • CAS No. 38956-79-5

  • Cat. No. CS-W006860
  • Purity≥97%
  • MDL No.MFCD00067771

*For research and further manufacturing use only, not for direct human use.

3-Hydrazinyl-6-methylpyridazine|CS-W006860

Structure of 38956-79-5

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General Information

  • CAS No. 38956-79-5
  • Cat. No. CS-W006860
  • Purity ≥97%
  • MDL No. MFCD00067771
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₈N₄
  • Molecular Weight 124.14
  • Synonym(s) 3-Methylpyridazin-6-ylhydrazine
  • SMILES N(N)C1=CC=C(N=N1)C

Description

3-Hydrazinyl-6-methylpyridazine is a bench-stable, electron-rich heterocycle featuring a hydrazino group at the 3-position and a methyl substituent at the 6-position. This configuration enables selective coupling reactions in synthetic pathways, particularly in the construction of nitrogen-rich scaffolds for medicinal chemistry applications.

Application

3-Hydrazinyl-6-methylpyridazine serves as a versatile building block in medicinal chemistry, enabling the construction of diverse heterocyclic scaffolds through cycloaddition and condensation reactions. Its hydrazinyl group facilitates facile derivatization, while the pyridazine core provides structural rigidity and favorable electronic properties for target-directed synthesis. The compound exhibits good bench stability and compatibility with standard purification methods, making it well-suited for iterative synthetic workflows in API development.

Synthesis

  • Route1

    References

    • DAIICHI PHARMACEUTICAL CO., LTD. Patent: EP1785418 A1, 2007 ; Location in patent: Page/Page column 53 ;
  • Route2

    References

    • DAIICHI PHARMACEUTICAL CO., LTD. Patent: EP1785418 A1, 2007 ; Location in patent: Page/Page column 38 ;
  • Route3

    References

    • Counotte-Potman, A.; Plas, H. C. van der Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1259 - 1261

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   63.83
  • LogP   0.07062
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   1

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