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CS-W001157 4
Total: USD 88.00

4-(Trifluoromethyl)benzimidamide hydrochloride

  • CAS No. 38980-96-0

  • Cat. No. CS-0021902
  • Molecule weight224.61
  • Purity≥97%
  • MDL No.MFCD04114431

*For research and further manufacturing use only, not for direct human use.

4-(Trifluoromethyl)benzimidamide hydrochloride|CS-0021902

Structure of 38980-96-0

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General Information

  • CAS No. 38980-96-0
  • Cat. No. CS-0021902
  • Purity ≥97%
  • MDL No. MFCD04114431
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈ClF₃N₂
  • Molecular Weight 224.61
  • Synonym(s) 4-(Trifluoromethyl)benzamidine hydrochloride
  • SMILES N=C(C1=CC=C(C(F)(F)F)C=C1)N.[H]Cl

Description

4-(Trifluoromethyl)benzimidamide hydrochloride features a trifluoromethyl group that imparts enhanced lipophilicity and metabolic stability, while the imidamide moiety provides a robust hydrogen-bonding scaffold. This combination enables efficient integration into bioactive scaffolds for medicinal chemistry applications.

Application

4-(Trifluoromethyl)benzimidamide hydrochloride serves as a versatile building block in medicinal chemistry, enabling efficient access to bioactive heterocycles. Its trifluoromethyl group enhances metabolic stability and membrane permeability, while the amide functionality supports diverse downstream transformations. The hydrochloride salt ensures excellent bench stability and ease of handling, facilitating straightforward purification and incorporation into coupling reactions or scaffold elaboration workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   49.87
  • LogP   2.41127
  • H_Acceptors   1
  • H_Donors   2
  • Rotatable_Bonds   1

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