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CS-W001157 4
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4-Chloro-7-fluoroquinoline

  • CAS No. 391-82-2

  • Cat. No. CS-0096779
  • Purity≥95%
  • MDL No.MFCD00153094

*For research and further manufacturing use only, not for direct human use.

4-Chloro-7-fluoroquinoline|CS-0096779

Structure of 391-82-2

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General Information

  • CAS No. 391-82-2
  • Cat. No. CS-0096779
  • Purity ≥95%
  • MDL No. MFCD00153094
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₅ClFN
  • Molecular Weight 181.59
  • Synonym(s) None
  • SMILES FC1=CC=C2C(Cl)=CC=NC2=C1

Description

4-Chloro-7-fluoroquinoline is a fluorinated quinoline derivative featuring complementary electron-withdrawing halogens at the 4- and 7-positions. This substitution pattern enhances its utility in conjugated systems, particularly as a fluorescent scaffold or building block in medicinal chemistry and materials science applications.

Application

4-Chloro-7-fluoroquinoline serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogen reactivity. The chlorine at C4 and fluorine at C7 offer orthogonal functionalization potential, facilitating sequential derivatization. Its high bench stability and ease of purification make it well-suited for scalable synthesis of quinoline-based pharmaceutical intermediates and kinase inhibitors.

Synthesis

  • Route1

    References

    • De, Dibyendu; Krogstad, Frances M.; Byers, Larry D.; Krogstad, Donald J. Journal of Medicinal Chemistry, 1998 , vol. 41, # 25 p. 4918 - 4926
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    • In-stock
      4-Chloro-7-fluoroquinoline|CS-0096779
      391-82-2

    References

    • Snyder et al. Journal of the American Chemical Society, 1947 , vol. 69, p. 371,373
  • Route3

    References

    • Matthews, Raymond S. Journal of Fluorine Chemistry, 1998 , vol. 91, # 2 p. 203 - 205

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   3.0273
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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