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Structure of 391-92-4
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Methyl 5-fluoro-2-hydroxybenzoate features a fluorinated aromatic ring paired with strategically positioned hydroxyl and ester functionalities. This combination enables selective reactivity in synthetic transformations, particularly in coupling reactions requiring electron-deficient aryl intermediates. The molecule exhibits enhanced stability under standard bench conditions and demonstrates favorable solubility in common organic solvents.
Methyl 5-fluoro-2-hydroxybenzoate serves as a versatile building block in medicinal chemistry and synthetic organic chemistry, enabling efficient access to bioactive heterocycles and functionalized aromatic scaffolds. The ortho-hydroxyl group facilitates intramolecular hydrogen bonding and enables directed metalation or electrophilic substitution, while the fluorine substituent enhances metabolic stability and modulates electronic properties. Its bench-stable nature and compatibility with standard coupling reactions make it well-suited for multi-step synthesis workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: