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Structure of 391900-69-9
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6-(tert-Butyl)nicotinaldehyde features a sterically hindered tert-butyl group at the pyridine ring's 6-position, enhancing stability and reducing unwanted side reactions. This electron-deficient aldehyde integrates readily into synthetic sequences requiring selective functionalization, offering improved handling under standard conditions.
6-(tert-Butyl)nicotinaldehyde serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the pyridine C6 position. Its aldehyde functionality facilitates reductive amination, Wittig reactions, and condensation with hydrazines or hydroxylamines. The tert-butyl group provides steric bulk and metabolic stability, enhancing pharmacokinetic properties. The compound exhibits excellent bench stability and ease of purification, making it suitable for scale-up and multi-step synthesis workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: