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CS-W001157 4
Total: USD 88.00

4,5-Dichloro-2-nitrophenol

  • CAS No. 39224-65-2

  • Cat. No. CS-0060123
  • Purity≥98%
  • MDL No.None
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4,5-Dichloro-2-nitrophenol|CS-0060123

Structure of 39224-65-2

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Description

4,5-Dichloro-2-nitrophenol features a nitro group flanked by two chlorine substituents on the aromatic ring, conferring strong electron-withdrawing character. This configuration enhances reactivity in nucleophilic substitution and facilitates incorporation into complex heterocycles. The compound exhibits bench-stable handling properties under standard conditions and serves as a key intermediate in agrochemical and pharmaceutical synthesis pathways.

Application

4,5-Dichloro-2-nitrophenol serves as a valuable building block in the synthesis of heterocyclic scaffolds and functionalized aromatic compounds. Its dual electron-withdrawing nitro and chlorine substituents enhance electrophilicity, facilitating nucleophilic aromatic substitution and palladium-catalyzed coupling reactions. The compound exhibits good bench stability and is compatible with standard purification methods, enabling efficient integration into multi-step synthetic sequences for pharmaceutical and agrochemical research.

General Information

  • CAS No. 39224-65-2
  • Cat. No. CS-0060123
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃Cl₂NO₃
  • Molecular Weight 208.00
  • Synonym(s) ,5-Dichloro-2-nitrophenol
  • SMILES C1=C(C(=CC(=C1[N+](=O)[O-])O)Cl)Cl

Computational Chemistry Data

  • TPSA   63.37
  • LogP   2.6072
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07,GHS09
Signal Word : Danger
UN#: 3077
Class : 9
Packing Group : Ⅲ
Hazard Statements : H302-H315-H317-H318-H410
Precautionary Statements : P261-P264-P270-P272-P273-P280-P302+P352-P330-P362+P364-P391-P501

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