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CS-W001157 4
Total: USD 88.00

3-Fluoroisonicotinic acid

  • CAS No. 393-53-3

  • Cat. No. CS-W001559
  • Purity≥98%
  • MDL No.MFCD03789251
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3-Fluoroisonicotinic acid|CS-W001559

Structure of 393-53-3

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Description

3-Fluoroisonicotinic acid is a fluorinated pyridine carboxylic acid featuring a strategically positioned electron-withdrawing fluoro group at the meta position. This substitution enhances acidity and metabolic stability, making it a valuable scaffold in medicinal chemistry for targeted drug design. The carboxylic acid functionality enables straightforward derivatization, while the aromatic core supports integration into diverse heterocyclic systems.

Application

3-Fluoroisonicotinic acid serves as a valuable building block in medicinal chemistry, enabling the synthesis of fluorinated heterocycles and bioactive compounds. Its ortho-fluorinated pyridine core provides enhanced metabolic stability and modulated electronic properties, facilitating efficient coupling reactions and functional group transformations. The compound exhibits good bench stability and is compatible with standard synthetic protocols, making it a practical choice for API development and process optimization.

General Information

  • CAS No. 393-53-3
  • Cat. No. CS-W001559
  • Purity ≥98%
  • MDL No. MFCD03789251
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄FNO₂
  • Molecular Weight 141.10
  • Synonym(s) T6NJ BF CVQ [WLN]
  • SMILES OC(=O)c1ccncc1F

Computational Chemistry Data

  • TPSA   50.19
  • LogP   0.9189
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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