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CS-W001157 4
Total: USD 88.00

2-Fluoronicotinic acid

  • CAS No. 393-55-5

  • Cat. No. CS-D0952
  • Purity≥97%
  • MDL No.MFCD00040744

*For research and further manufacturing use only, not for direct human use.

2-Fluoronicotinic acid|CS-D0952

Structure of 393-55-5

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General Information

  • CAS No. 393-55-5
  • Cat. No. CS-D0952
  • Purity ≥97%
  • MDL No. MFCD00040744
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄FNO₂
  • Molecular Weight 141.10
  • Synonym(s) Toluene, 4-chloro-.alpha.,.alpha.,.alpha.-trifluoro-3,5-dinitro-
  • SMILES O=C(C1=CC=CN=C1F)O

Description

2-Fluoronicotinic acid features a fluorine atom at the ortho position relative to the carboxylic acid group on a pyridine ring, enhancing its electron-withdrawing character and metabolic stability. This structural motif enables integration into bioactive molecules where targeted polarity and binding affinity are critical.

Application

2-Fluoronicotinic acid serves as a versatile building block in medicinal chemistry, enabling direct incorporation of a fluorinated pyridine moiety into target molecules. Its carboxylic acid functionality facilitates amide coupling and esterification, while the ortho-fluoro substituent enhances metabolic stability and modulates electronic properties. The compound exhibits good bench stability and compatibility with standard purification techniques, making it well-suited for use in API synthesis and heterocyclic scaffold development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   0.9189
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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