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CS-W001157 4
Total: USD 88.00

2-Fluoronicotinic acid

  • CAS No. 393-55-5

  • Cat. No. CS-D0952
  • Purity≥97%
  • MDL No.MFCD00040744
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2-Fluoronicotinic acid|CS-D0952

Structure of 393-55-5

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Description

2-Fluoronicotinic acid features a fluorine atom at the ortho position relative to the carboxylic acid group on a pyridine ring, enhancing its electron-withdrawing character and metabolic stability. This structural motif enables integration into bioactive molecules where targeted polarity and binding affinity are critical.

Application

2-Fluoronicotinic acid serves as a versatile building block in medicinal chemistry, enabling direct incorporation of a fluorinated pyridine moiety into target molecules. Its carboxylic acid functionality facilitates amide coupling and esterification, while the ortho-fluoro substituent enhances metabolic stability and modulates electronic properties. The compound exhibits good bench stability and compatibility with standard purification techniques, making it well-suited for use in API synthesis and heterocyclic scaffold development.

General Information

  • CAS No. 393-55-5
  • Cat. No. CS-D0952
  • Purity ≥97%
  • MDL No. MFCD00040744
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄FNO₂
  • Molecular Weight 141.10
  • Synonym(s) Toluene, 4-chloro-.alpha.,.alpha.,.alpha.-trifluoro-3,5-dinitro-
  • SMILES O=C(C1=CC=CN=C1F)O

Computational Chemistry Data

  • TPSA   50.19
  • LogP   0.9189
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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