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Structure of 393-85-1
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Methyl 5-fluoro-2-nitrobenzoate features a fluorinated aromatic ring paired with strategically positioned nitro and ester groups, enabling direct incorporation into cross-coupling reactions. The electron-deficient benzene core facilitates nucleophilic substitution, while the methyl ester serves as a reactive handle for downstream derivatization under mild conditions. This compound exhibits bench-stable handling characteristics and compatibility with standard synthetic protocols.
Methyl 5-fluoro-2-nitrobenzoate serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted benzimidazoles and other heterocyclic scaffolds via standard coupling and cyclization protocols. The ortho-nitro and fluoro groups exhibit complementary reactivity, facilitating sequential functionalization with high regiocontrol. Its bench-stable nature and compatibility with common reaction conditions make it suitable for multi-step synthesis workflows in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: