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CS-W001157 4
Total: USD 88.00

4-Methoxybenzene-1,2-diol

  • CAS No. 3934-97-2

  • Cat. No. CS-0160866
  • Molecule weight140.14
  • Purity≥97%
  • MDL No.MFCD18395726

*For research and further manufacturing use only, not for direct human use.

4-Methoxybenzene-1,2-diol|CS-0160866

Structure of 3934-97-2

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General Information

  • CAS No. 3934-97-2
  • Cat. No. CS-0160866
  • Purity ≥97%
  • MDL No. MFCD18395726
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈O₃
  • Molecular Weight 140.14
  • Synonym(s) p-Methoxycatechol
  • SMILES OC1=CC=C(OC)C=C1O

Description

4-Methoxybenzene-1,2-diol features a catechol core substituted with a methoxy group at the para position, enhancing solubility and stability. This arrangement imparts strong electron-donating character, making it valuable for metal chelation and redox-active applications. The molecule exhibits robust bench-stability under standard conditions, enabling reliable use in synthetic and analytical workflows.

Application

4-Methoxybenzene-1,2-diol serves as a versatile phenolic building block for the synthesis of bioactive heterocycles and natural product analogs. Its ortho-dihydroxy motif enables reliable metal-catalyzed coupling reactions and oxidative cyclization pathways, while the methoxy group enhances solubility and modulates reactivity. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for iterative synthetic sequences in medicinal chemistry and process development workflows.

Synthesis

  • Route1

    References

    • Bernet, Andreas; Seifert, Karlheinz Helvetica Chimica Acta, 2006 , vol. 89, # 4 p. 784 - 796
  • Route2
    • null|null
      88755-15-1
    • ~88%
    • In-stock
      4-Methoxybenzene-1,2-diol|CS-0160866
      3934-97-2

    References

    • Aihara, Kazuhiro; Urano, Yasuteru; Higuchi, Tsunehiko; Hirobe, Masaaki Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1993 , # 11 p. 2165 - 2170
  • Route3

    References

    • Saito, Shizuka; Kawabata, Jun Tetrahedron, 2005 , vol. 61, # 34 p. 8101 - 8108

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   49.69
  • LogP   1.1064
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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