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Structure of 394-46-7
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1-Fluoro-2-vinylbenzene features a conjugated vinyl group adjacent to a fluorinated aromatic ring, enabling efficient coupling in palladium-catalyzed cross-coupling reactions. The electron-withdrawing fluorine stabilizes the intermediate aryl radical, enhancing reactivity in cascade cyclizations and functionalization sequences. This bench-stable, moisture-tolerant reagent integrates seamlessly into synthetic pathways requiring selective C–C bond formation under mild conditions.
1-Fluoro-2-vinylbenzene serves as a versatile building block for transition-metal-catalyzed cross-coupling reactions, enabling the efficient construction of biaryl and styrenyl architectures. The vinyl group facilitates Heck and Suzuki-Miyaura couplings, while the ortho-fluorine supports directed functionalization and palladium-catalyzed C–H activation. Its bench-stable nature and compatibility with diverse reaction conditions make it a practical choice for synthesizing complex aromatic scaffolds in medicinal chemistry and materials science applications.
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GHS Pictogram :
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GHS No : GHS02
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Signal Word : Warning
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UN#: 1993
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Class : 3
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Packing Group : Ⅲ
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Hazard Statements : H226
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Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P370+P378-P501
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Lot numbers can be found on the outside label of a product: