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Structure of 394-59-2
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This trifluoromethyl aryl ketone features a sterically hindered, electron-deficient carbonyl group flanked by a para-tolyl substituent. The trifluoromethyl moiety enhances metabolic stability and lipophilicity, making it ideal for synthetic intermediates in pharmaceutical development.
2,2,2-Trifluoro-1-(p-tolyl)ethanone serves as a versatile building block in synthetic organic chemistry, enabling efficient construction of fluorinated aromatic systems. Its trifluoromethyl ketone functionality exhibits high electrophilicity and stability under standard reaction conditions, facilitating nucleophilic additions, enolization, and subsequent functionalization. The p-tolyl group provides steric and electronic modulation, enhancing solubility and compatibility with common coupling protocols. This compound functions reliably in multistep syntheses requiring bench-stable, selectively reactive intermediates for pharmaceutical and agrochemical development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: