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CS-W001157 4
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1-(3-Chloropropyl)pyrrolidine

  • CAS No. 39743-20-9

  • Cat. No. CS-0155277
  • Molecule weight147.65
  • Purity≥95%
  • MDL No.MFCD07787234

*For research and further manufacturing use only, not for direct human use.

1-(3-Chloropropyl)pyrrolidine|CS-0155277

Structure of 39743-20-9

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General Information

  • CAS No. 39743-20-9
  • Cat. No. CS-0155277
  • Purity ≥95%
  • MDL No. MFCD07787234
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₄ClN
  • Molecular Weight 147.65
  • Synonym(s) N-CHLOROPROPYL PYRROLIDINE
  • SMILES C1CCN(C1)CCCCl

Description

1-(3-Chloropropyl)pyrrolidine features a pyrrolidine ring linked to a chlorinated propyl chain, enabling versatile functionalization in synthetic chemistry. This scaffold delivers enhanced nucleophilicity and stability under standard conditions, facilitating efficient coupling reactions. The terminal chloride group serves as a reactive handle for cross-coupling or substitution processes.

Application

1-(3-Chloropropyl)pyrrolidine serves as a versatile bifunctional building block in medicinal chemistry, enabling efficient incorporation of both amine and alkyl chloride functionalities. The chloropropyl side chain facilitates SN2 reactions with nucleophiles, while the pyrrolidine nitrogen supports salt formation and hydrogen bonding. Its bench-stable nature and compatibility with diverse reaction conditions make it well-suited for modular synthesis of bioactive compounds, including receptor ligands and kinase inhibitors.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1760
Class : 8
Packing Group : Ⅱ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

  • TPSA   3.24
  • LogP   1.7111
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   3

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