4,4'-Difluoro-1,1'-biphenyl

Name: 4,4'-Difluoro-1,1'-biphenyl
Brand: ChemScene
Availability: InStock
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CAS No. 398-23-2
Cat. No. CS-M2784
Purity≥98%
MDL No.MFCD00000349

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Structure of 398-23-2

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Description

4,4'-Difluoro-1,1'-biphenyl features two fluorine atoms at the para positions of a biphenyl scaffold, delivering enhanced electron-withdrawal and improved metabolic stability. This configuration enables efficient coupling in transition-metal catalyzed reactions, particularly in Suzuki-Miyaura and Buchwald-Hartwig processes. The compound exhibits excellent bench stability and solubility in common organic solvents, facilitating its use in synthetic workflows for pharmaceutical intermediates and functional materials.

Application

4,4'-Difluoro-1,1'-biphenyl serves as a versatile building block in cross-coupling reactions, enabling efficient construction of biaryl scaffolds under palladium-catalyzed conditions. The ortho-fluorine substituents provide enhanced stability and facilitate selective functionalization, while the biphenyl core offers rigidity and favorable electronic properties for pharmaceutical and materials applications. Its bench-stable nature and compatibility with standard coupling protocols make it a practical choice for iterative synthesis.

General Information

CAS No. 398-23-2
Cat. No. CS-M2784
Purity ≥98%
MDL No. MFCD00000349
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₈F₂
Molecular Weight None
Synonym(s) N-(4-fluorobenzyl)-N',N'-dimethyl-N-(pyridin-2-yl)ethane-1,2-diamine
SMILES FC(C=C1)=CC=C1C2=CC=C(F)C=C2

Computational Chemistry Data

TPSA 0
LogP 3.6318
H_Acceptors 0
H_Donors 0
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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4,4'-Difluoro-1,1'-biphenyl

CAS No. 398-23-2

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