Lot numbers can be found on the outside label of a product:
6-Chloro-9-[2,3-O-(1-methylethylidene)-beta-D-ribofuranosyl]-9H-Purine
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CAS No. 39824-26-5
- Cat. No. CS-W000282
- Purity≥97%
- MDL No.MFCD03788833
*For research and further manufacturing use only, not for direct human use.
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Structure of 39824-26-5
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General Information
- CAS No. 39824-26-5
- Cat. No. CS-W000282
- Purity ≥97%
- MDL No. MFCD03788833
- Storage -20°C, sealed storage, away from moisture
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₃H₁₅ClN₄O₄
- Molecular Weight 326.74
- Synonym(s) 6-Chloropurine-9-(2,3-isopropylidene-β-D-ribofuranoside)
- SMILES CC1(C)O[C@H]2[C@@H](O1)[C@H](N3C(N=CN=C4Cl)=C4N=C3)O[C@@H]2CO
Description
6-Chloro-9-[2,3-O-(1-methylethylidene)-beta-D-ribofuranosyl]-9H-Purine features a protected ribose moiety that enhances stability and facilitates controlled incorporation into nucleic acid analogs. The chlorinated purine base supports efficient coupling in oligonucleotide synthesis workflows, offering improved resistance to hydrolysis under standard conditions.
Application
6-Chloro-9-[2,3-O-(1-methylethylidene)-β-D-ribofuranosyl]-9H-purine serves as a key nucleoside building block for the synthesis of antiviral agents and purine-based pharmaceutical intermediates. The protected ribose moiety enhances stability and facilitates selective functionalization at the C-6 position. Its well-documented reactivity enables reliable glycosylation and coupling protocols in medicinal chemistry workflows, supporting scalable synthesis of nucleoside analogs with proven biological activity.
Synthesis
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Route1
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In-stock
2004-06-0 -
67-64-1 - ~95%
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In-stock
39824-26-5
References
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Zhu, Zhengxiang; Buolamwini, John K. Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 7 p. 3848 - 3865
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Route2
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In-stock
2004-06-0
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77-76-9
- ~99%
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In-stock
39824-26-5
References
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MILLENNIUM PHARMACEUTICALS, INC. Patent: WO2006/84281 A1, 2006 ; Location in patent: Page/Page column 78-79 ;
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Route3
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3181-38-2 - ~%
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In-stock
39824-26-5
References
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Camp, David; Li, Ying; McCluskey, Adam; Moni, Roger W.; Quinn, Ronald J. Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 6 p. 695 - 698
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 91.52
- LogP 0.8895
- H_Acceptors 8
- H_Donors 1
- Rotatable_Bonds 2
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Key Words
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