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Structure of 400-74-8
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1-Fluoro-4-nitro-2-(trifluoromethyl)benzene features a trifluoromethyl group flanked by electron-withdrawing fluorine and nitro substituents, creating a highly electron-deficient aromatic core. This structural motif enables efficient coupling in transition metal-catalyzed reactions, particularly in cross-coupling and nucleophilic aromatic substitution processes. The compound exhibits excellent stability under standard bench conditions and facilitates the rapid assembly of complex fluorinated scaffolds in medicinal chemistry and materials science applications.
1-Fluoro-4-nitro-2-(trifluoromethyl)benzene serves as a versatile building block in medicinal chemistry, enabling direct nucleophilic aromatic substitution (SNAr) under mild conditions due to the strong electron-withdrawing effects of both the nitro and trifluoromethyl groups. Its bench-stable nature and compatibility with diverse amines, thiols, and alkoxides facilitate efficient access to functionalized aryl scaffolds commonly found in agrochemicals and pharmaceutical intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: