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CS-W001157 4
Total: USD 88.00

2-Fluoro-5-methoxybenzamide

  • CAS No. 400-92-0

  • Cat. No. CS-0192195
  • Molecule weight169.15
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-5-methoxybenzamide|CS-0192195

Structure of 400-92-0

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General Information

  • CAS No. 400-92-0
  • Cat. No. CS-0192195
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈FNO₂
  • Molecular Weight 169.15
  • Synonym(s) None
  • SMILES COC1=CC(C(N)=O)=C(F)C=C1

Description

2-Fluoro-5-methoxybenzamide features a fluorine atom at the ortho position and a methoxy group at the para position relative to the amide, creating a polar, electron-deficient aromatic scaffold. This combination enhances solubility and metabolic stability while enabling selective interactions in medicinal chemistry applications.

Application

2-Fluoro-5-methoxybenzamide serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its ortho-fluoro and meta-methoxy substituents provide favorable electronic modulation and enhanced metabolic stability. The amide functionality offers robust compatibility with standard coupling reactions and facilitates purification via crystallization or chromatography, making it well-suited for scalable synthesis and process development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   52.32
  • LogP   0.9332
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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