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2-(4-Fluorophenyl)propan-2-ol

  • CAS No. 402-41-5

  • Cat. No. CS-0154631
  • Molecule weight154.18
  • Purity≥97%
  • MDL No.MFCD00059919

*For research and further manufacturing use only, not for direct human use.

2-(4-Fluorophenyl)propan-2-ol|CS-0154631

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General Information

  • CAS No. 402-41-5
  • Cat. No. CS-0154631
  • Purity ≥97%
  • MDL No. MFCD00059919
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₁FO
  • Molecular Weight 154.18
  • Synonym(s) 4-Fluoro-alpha,alpha-dimethyl-benzenemethanol
  • SMILES CC(C)(C1=CC=C(C=C1)F)O

Description

This bench-stable fluorinated alcohol features a sterically hindered tertiary carbon center, enabling reliable integration into complex synthetic sequences. The para-fluorophenyl moiety imparts enhanced metabolic stability and favorable lipophilicity, making it a valuable scaffold in medicinal chemistry applications.

Application

2-(4-Fluorophenyl)propan-2-ol serves as a valuable chiral building block in medicinal chemistry, offering a stable tertiary alcohol functionality with enhanced metabolic resistance due to the fluorine substituent. Its bench-stable nature and compatibility with standard functional group transformations facilitate efficient incorporation into pharmaceutical scaffolds, particularly in the synthesis of kinase inhibitors and CNS-active compounds.

Synthesis

  • Route1

    References

    • Arnold, Donald R.; Nicholas, A. Martin de P.; Snow, Miles S. Canadian Journal of Chemistry, 1985 , vol. 63, p. 1150 - 1156
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    • In-stock
      2-(4-Fluorophenyl)propan-2-ol|CS-0154631
      402-41-5

    References

    • Forsyth, David A.; Lucas, Peter; Burk, Robert M. Journal of the American Chemical Society, 1982 , vol. 104, # 1 p. 240 - 245
  • Route3

    References

    • Popielarz; Arnold Journal of the American Chemical Society, 1990 , vol. 112, # 8 p. 3068 - 3082

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P302+P352-P304+P340

Quality Control

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   2.0531
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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