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Structure of 402-66-4
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5-Fluoronicotinic acid is a bench-stable, electron-deficient heterocyclic carboxylic acid featuring a fluorine atom at the 5-position of the pyridine ring. This substitution enhances its utility in synthetic routes requiring polarized C–H bonds or improved solubility in aqueous-organic mixtures. It integrates readily into pharmaceutical intermediates and bioactive molecule scaffolds through standard amide coupling and electrophilic functionalization protocols.
5-Fluoronicotinic acid serves as a valuable building block in medicinal chemistry, enabling the synthesis of fluorinated heterocycles and bioactive scaffolds. Its ortho-fluoro substitution enhances metabolic stability and modulates electronic properties, while the carboxylic acid functionality facilitates direct coupling or derivatization. The compound exhibits excellent bench stability and compatibility with standard peptide coupling and esterification protocols, making it a practical choice for scalable synthesis and structure-activity studies.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: