Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

Ethyl 2-(5-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)acetate

  • CAS No. 402948-37-2

  • Cat. No. CS-0008237
  • Molecule weight302.37
  • Purity≥98%
  • MDL No.MFCD10565679

*For research and further manufacturing use only, not for direct human use.

Ethyl 2-(5-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)acetate|CS-0008237

Structure of 402948-37-2

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 402948-37-2
  • Cat. No. CS-0008237
  • Purity ≥98%
  • MDL No. MFCD10565679
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₆H₂₂N₄O₂
  • Molecular Weight 302.37
  • Synonym(s) Ethyl 2-[5-(4-methylpiperazinyl)benzimidazol-2-yl]acetate
  • SMILES CN(CC1)CCN1C2=CC=C(NC(CC(OCC)=O)=N3)C3=C2

Description

Ethyl 2-(5-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)acetate features a benzimidazole core functionalized with a methylpiperazine moiety and an ethyl ester group, enabling direct incorporation into medicinal chemistry campaigns. This compound serves as a key scaffold for targeted kinase inhibitors and bioactive heterocycles.

Application

Ethyl 2-(5-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)acetate serves as a versatile building block for medicinal chemistry campaigns, enabling efficient access to bioactive heterocyclic scaffolds. The molecule combines a stable benzo[d]imidazole core with a pendant ethyl acetate group, facilitating downstream functionalization via hydrolysis or nucleophilic substitution. Its moderate solubility and bench stability support reliable handling in multi-step syntheses, while the 4-methylpiperazine moiety offers favorable polarity and hydrogen-bonding capacity for target engagement.

Synthesis

  • Route1
    • In-stock
      Ethyl 3-ethoxy-3-iminopropanoate hydrochloride|CS-W019993
      2318-25-4
    • null|null
      54998-08-2
    • ~94%
    • In-stock
      Ethyl 2-(5-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)acetate|CS-0008237
      402948-37-2

    References

    • Novartis AG Patent: US2008/293738 A1, 2008 ; Location in patent: Page/Page column 11; 13-14 ;
  • Route2

    References

    • CHIRON CORPORATION Patent: US2005/256157 A1, 2005 ; US 20050256157 A1
  • Route3

    References

    • Zhu, Shuguang; Harwood, Eric; Cai, Shaopei; Shang, Xiao; Galvin, Gabriel; Jin, Li; Yeung, Arthur; Diaz, Brian; Zheng, Minna; Ryckman, David Chimia, 2006 , vol. 60, # 9 p. 584 - 592

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   61.46
  • LogP   1.4203
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   4

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 402948-37-2 sigma402948-37-2 manufacturer402948-37-2 price402948-37-2 structure402948-37-2 SDSbuy 402948-37-2402948-37-2 supplier402948-37-2 uses402948-37-2 molecular weightprice of 402948-37-2402948-37-2 chemical name formula of 402948-37-2
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label