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Structure of 403-16-7
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3-Chloro-4-fluorobenzoic acid features a strategically positioned chloro and fluoro substituent on the aromatic ring, delivering enhanced electron-withdrawal and metabolic stability. This combination improves solubility in organic media while maintaining crystalline purity. The carboxylic acid group enables direct coupling reactions or salt formation for downstream derivatization in medicinal chemistry and agrochemical synthesis.
3-Chloro-4-fluorobenzoic acid serves as a versatile building block in medicinal chemistry and agrochemical synthesis, offering orthogonal halogen handles for subsequent cross-coupling reactions. Its carboxylic acid functionality enables direct derivatization into amides, esters, or acyl chlorides, while the meta-chloro and para-fluoro substituents provide excellent functional group tolerance and predictable reactivity in palladium-catalyzed transformations. The compound exhibits good bench stability and ease of purification, making it well-suited for scalable synthesis workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: