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Structure of 403-24-7
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2-Fluoro-4-nitrobenzoic acid features a fluorine atom at the ortho position and a nitro group at the para position relative to the carboxylic acid, creating a strongly electron-deficient aromatic ring. This combination enhances reactivity in nucleophilic substitution and facilitates coupling reactions under mild conditions. The compound exhibits excellent bench stability and solubility in common organic solvents, enabling straightforward incorporation into synthetic workflows for pharmaceutical intermediates and functional materials.
2-Fluoro-4-nitrobenzoic acid serves as a versatile building block in medicinal chemistry and synthetic organic chemistry, enabling efficient access to functionalized aromatic scaffolds. Its orthogonal reactivity—combining a carboxylic acid for derivatization and complementary fluorine/nitro groups for further transformation—facilitates late-stage functionalization. The compound exhibits excellent bench stability, simplifies purification, and participates reliably in coupling reactions, nucleophilic aromatic substitution, and heterocycle formation under standard conditions.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: