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CS-W001157 4
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4-Hydroxy-1-methyl-1,2-dihydropyridin-2-one

  • CAS No. 40357-87-7

  • Cat. No. CS-0309246
  • Molecule weight125.13
  • Purity≥97%
  • MDL No.MFCD01646151

*For research and further manufacturing use only, not for direct human use.

4-Hydroxy-1-methyl-1,2-dihydropyridin-2-one|CS-0309246

Structure of 40357-87-7

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General Information

  • CAS No. 40357-87-7
  • Cat. No. CS-0309246
  • Purity ≥97%
  • MDL No. MFCD01646151
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇NO₂
  • Molecular Weight 125.13
  • Synonym(s) 4-Hydroxy-1-methyl-2-pyridone
  • SMILES CN1C=CC(=CC1=O)O

Description

4-Hydroxy-1-methyl-1,2-dihydropyridin-2-one is a bench-stable heterocyclic scaffold featuring a conjugated enolizable carbonyl and a nitrogen-rich core. This structure integrates readily into synthetic sequences requiring electron-rich dihydropyridine motifs, offering enhanced reactivity in transition-metal-catalyzed couplings and enabling efficient access to bioactive alkaloid analogs under standard conditions.

Application

4-Hydroxy-1-methyl-1,2-dihydropyridin-2-one serves as a versatile building block in medicinal chemistry, enabling efficient access to pyridone-based scaffolds. Its stability under ambient conditions and compatibility with diverse functional groups facilitate straightforward derivatization via nucleophilic substitution or metal-catalyzed coupling reactions. The molecule functions as a key intermediate in the synthesis of bioactive heterocycles and offers predictable reactivity for use in high-throughput screening campaigns and process-scale applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   42.23
  • LogP   0.0909
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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