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CS-W001157 4
Total: USD 88.00

4-Methoxypiperidine hydrochloride

  • CAS No. 4045-25-4

  • Cat. No. CS-W005038
  • Molecule weight151.63
  • Purity≥97%
  • MDL No.MFCD06800959

*For research and further manufacturing use only, not for direct human use.

4-Methoxypiperidine hydrochloride|CS-W005038

Structure of 4045-25-4

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General Information

  • CAS No. 4045-25-4
  • Cat. No. CS-W005038
  • Purity ≥97%
  • MDL No. MFCD06800959
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₄ClNO
  • Molecular Weight 151.63
  • Synonym(s) 4-Methoxypiperidine Monohydrochloride
  • SMILES COC1CCNCC1.[H]Cl

Description

4-Methoxypiperidine hydrochloride is a bench-stable, moisture-tolerant heterocyclic amine featuring a methoxy group at the 4-position of the piperidine ring. This electron-donating substituent enhances solubility and modulates basicity, enabling efficient incorporation into pharmaceutical intermediates and bioactive molecules. The salt form ensures improved crystallinity and handling in synthetic workflows.

Application

4-Methoxypiperidine hydrochloride serves as a versatile nitrogen-containing building block in medicinal chemistry, enabling efficient access to diverse heterocyclic scaffolds. Its piperidine core exhibits favorable basicity and solubility, while the methoxy group provides a handle for further functionalization. The hydrochloride salt ensures excellent bench stability, ease of handling, and compatibility with standard coupling reactions, facilitating its use in peptide conjugation, macrocyclization, and targeted synthesis of bioactive compounds.

Synthesis

  • Route1

    References

    • H. LUNDBECK A/S Patent: US2011/92475 A1, 2011 ; Location in patent: Page/Page column 18 ;
  • Route2
    • null|null
      5382-16-1
    • null|null
      74-88-4
    • ~33%
    • In-stock
      4-Methoxypiperidine hydrochloride|CS-W005038
      4045-25-4

    References

    • GLAXOSMITHKLINE LLC; HAMMOND, Marlys; KALLANDER, Lara, S.; LAWHORN, Brian, Griffin; PHILP, Joanne; SARPONG, Martha, A.; SEEFELD, Mark, Andrew Patent: WO2011/149827 A1, 2011 ; Location in patent: Page/Page column 149-150 ;
  • Route3
    • null|null
      109384-19-2
    • ~%
    • In-stock
      4-Methoxypiperidine hydrochloride|CS-W005038
      4045-25-4

    References

    • H. LUNDBECK A/S Patent: US2011/92475 A1, 2011 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   21.26
  • LogP   0.8066
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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